Low Calorie, High Protein Options at Domino's Pizza (November 2025)

Nov 5

November 2025 update

You can absolutely fit Domino’s into a cut or a “hit my protein” day—if you think in slices, anchor your meal with chicken or wings, and treat dips like dessert. Nutrition varies a bit by location and how heavy the toppings land in the kitchen, so the numbers below are practical 2025 ranges to help you order fast and feel full.

The Shortlist (fast wins)

Large Thin-Crust Pepperoni — per slice (1/8): ~210–250 kcal • ~10–12 g protein • ~20–22 g carbs • ~10–15 g fat
Classic taste with the best “slice efficiency.”
Large Hand-Tossed Pepperoni — per slice (1/8): ~280–320 kcal • ~12–14 g protein • ~26–30 g carbs • ~12–16 g fat
A little more protein than thin, with extra calories.
Large Thin, Build-Your-Own (Chicken + Veg) — per slice (1/8): ~230–260 kcal • ~12–14 g protein
Top choice for protein-per-calorie; stack mushrooms, onions, banana peppers, jalapeños, tomatoes for volume.
Wings (plain or Buffalo):
Bone-in (8–10 pc order): ~600–850 kcal • ~50–70 g protein
Boneless (10 pc): ~600–650 kcal • ~35–40 g protein
Best protein side; Buffalo adds flavor with minimal calories compared to creamy dips.

Per-Slice Pizza Macros (so you can plan your order)

Slice math: Large = 8 slices for Hand-Tossed/Thin, 6 slices for Brooklyn. Plan your night around how many slices you’ll eat before you open the box.

One-Topping Staples (Large pies)

Thin-Crust Pepperoni — per slice (1/8): ~210–250 kcal • ~10–12 g P
Hand-Tossed Pepperoni — per slice (1/8): ~280–320 kcal • ~12–14 g P
Hand-Tossed Cheese — per slice (1/8): ~270–290 kcal • ~11–13 g P

Brooklyn & Pan (for context)

Brooklyn Pepperoni — per slice (1/6): ~290 kcal • ~13 g P
Handmade Pan (12″) Pepperoni — per slice: typically ~300–330 kcal • ~12–14 g P (heavier crust; verify in-app if you’re strict).

Gluten-Free (10″ small)

Cheese — per slice (1/6): ~140–170 kcal • ~5–7 g P
Protein is lower per slice; pair with a protein side if you need numbers.

“Protein Topping” Strategy

Grilled Chicken: usually +1–2 g protein per slice for a modest calorie bump—your best protein add.
Extra meats (pepperoni/sausage/bacon): more protein and more fat/sodium—use when you can afford the calories.
Veggies: near-zero calories, big chew/crunch; a free way to feel full on 2 slices instead of 3.

Wings & Chicken (your protein anchor)

Bone-In/Traditional Wings (plain or Buffalo):
Small/medium orders commonly land ~50–70 g protein for ~600–850 kcal total (size and sauce vary).
Buffalo/hot sauces tend to be very low-cal; sodium climbs.
Boneless Wings:
10-pc ~600–650 kcal • ~35–40 g protein.
Great add if you prefer boneless; protein isn’t as dense as bone-in.

Ordering tips:

Choose plain or Buffalo to keep calories tighter.
Keep ranch/garlic-parm to a tiny dip—amazing, but calorie-dense.

Dips, Sauces & “Stealth Calories” (per cup/packet, typical)

Hot Buffalo dipping cup: ~15 kcal (sodium heavy; flavor bomb, low calories).
Garlic dipping cup: ~250 kcal (mostly fat; treat like dessert).
Ranch dipping cup: ~160–200 kcal (portion sizes vary).
BBQ packet: ~45–60 kcal.
Ketchup: ~15–20 kcal; Mustard: ~0–5 kcal.

Playbook: pick one rich dip (or go half), and stack the rest of your flavor with banana peppers, jalapeños, extra tomatoes, and Buffalo/mustard.

Ready-to-Order Combos (copy/paste)

~450–550 kcal • ~25–35 g protein

2 slices Large Thin-Crust Pepperoni + water or diet soda.
1 slice Large Thin (Chicken + Veg) + 4–5 boneless wings (plain/Buffalo).

~600–700 kcal • ~35–45 g protein

2 slices Large Hand-Tossed Pepperoni + 3–4 boneless wings (Buffalo) (skip creamy dips).
2 slices Large Thin (Chicken + Veg) + light BBQ or mustard.

~800–900 kcal • ~45–60 g protein

2 slices Hand-Tossed Pepperoni + 6–8 boneless wings (Buffalo/plain).
3 slices Large Thin-Crust Pepperoni + side salad at home for fiber/volume.

Quick Picks by Goal

Leanest “real pizza” feel: Large Thin (Chicken + Veg) — ~230–260 kcal • ~12–14 g P per slice.
Classic pepperoni, still tidy: Large Thin Pepperoni — ~210–250 kcal • ~10–12 g P.
Big protein add-on: Bone-in wings (plain/Buffalo) — ~50–70 g protein per order.
Lower-cal full meal under ~550 kcal: 2 thin slices or 1 protein-loaded slice + ~5 boneless wings.

Smart Swaps That Save Big Calories (without losing flavor)

Thin > Hand-Tossed > Pan when you plan to eat multiple slices.
Chicken + veg > extra cheese/meats for protein without the same fat jump.
Buffalo or mustard > creamy dips (save the garlic cup for one intentional bite).
Hydrate + potassium (banana, yogurt, beans) later—pizza/wings nights run salty.
Pre-commit your slice count before you open the box (2 slices + protein side beats 3–4 slices alone).

“Build Rules” You Can Memorize

Two rich things, max: pick any two of (extra cheese, extra meat, creamy dip).
Anchor with protein: wings or chicken topping, every time.
Veg for volume: ask for double mushrooms/onions/banana peppers on thin crust so two slices feel like a meal.
Count dips: one garlic cup is a slice-worth of calories.

Sample Day Templates

Cut Day (~1,900 kcal target)

Lunch: 2 slices Large Thin Pepperoni (~420–500 kcal, ~20–24 g P)
Dinner: Chicken/veg bowl at home (~500 kcal, ~40 g P)
Snacks: Greek yogurt + fruit (~250 kcal, ~20 g P)
→ Leaves room for coffee/extra snacks while staying on track.

Lift Day (~2,400 kcal target)

Dinner: 2 slices Hand-Tossed Pepperoni (~560–640 kcal, ~24–28 g P) + 6 boneless wings (~360–400 kcal, ~20–25 g P)
Add a protein shake post-workout and veg for sodium balance.

Last Bite: Slices + Wings = Macro Wins 🏆

Domino’s doesn’t have to blow your goals. Stick with thin crust, chicken + veg for protein, go Buffalo over creamy dips, and add wings to round out the meal. Share your calorie + protein target and I’ll turn this into ready-to-order Domino’s sets you can rotate on game nights and busy weeks.